The preparation and Birch reduction of a 1,3,4-tri-substituted pyrrole is described: the heterocycle is loaded with electron-withdrawing groups and undergoes a double reductive alkylation reaction to yield cis-3,4-disubstituted pyrrolidines.
T. J. Donohoe, R. R. Harji and R. P. C. Cousins, Chem. Commun., 1999, 141 DOI: 10.1039/A809193E
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