Catalytic asymmetric carbon–carbon bond forming reactions: preparation of optically enriched 2-aryl propionic acids by a catalytic asymmetric hydroboration–homologation sequence†
Abstract
A new catalytic asymmetric one-carbon homologation strategy has been developed which employs a rhodium catalyzed asymmetric hydroboration followed by homologation with LiCHCl2 and oxidation to generate 2-arylpropionic acids of high enantiomeric purity.