Highly active supported palladium catalyst for the regioselective synthesis of 2-arylpropionic acids by carbonylation
Abstract
A catalyst system consisting of supported palladium in the presence of phosphine ligands, TsOH and LiCl catalyses the carbonylation of 1-arylethanols to 2-arylpropionic acids with significantly improved activity and regioselectivity; the catalyst can be recycled with no loss in activity and selecivity.