Issue 5, 2000
From the journal:

Chemical Communications

Design of a nucleobase-conjugated peptide that recognizes HIV-1 RRE IIB RNA with high affinity and specificity

Tsuyoshi Takahashi,a   Keita Hamasaki,a   Ichiro Kumagai,a   Akihiko Uenoa  and  Hisakazu Mihara*a  

* Corresponding authors

a Department of Bioengineering, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta, Japan.
E-mail: hmihara@bio.titech.ac.jp

b Form and Function, PRESTO, Japan Science and Technology Corporation, Tokyo Institute of Technology, Nagatsuta, Japan

Abstract

A nucleobase-conjugated peptide, derived from HIV-1 Rev, was designed and synthesized, and the peptide which contained the cytosine moiety at the L-α-amino acid side chain bound RRE IIB RNA with high affinity and high specificity.

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Article information

DOI
https://doi.org/10.1039/A909579I
Article type
Communication
Submitted
06 Dec 1999
Accepted
26 Jan 2000
First published
21 Feb 2000

Chem. Commun., 2000, 349-350

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Design of a nucleobase-conjugated peptide that recognizes HIV-1 RRE IIB RNA with high affinity and specificity

T. Takahashi, K. Hamasaki, I. Kumagai, A. Ueno and H. Mihara, Chem. Commun., 2000, 349 DOI: 10.1039/A909579I

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