Issue 6, 2000

Unnatural natural triterpenes produced by altering isoleucine into alanine at position 261 in hopene synthase and the importance of having the appropriate bulk size at this position for directing the stereochemical destiny during the polycyclization cascadeElectronic supplementary information (ESI) available: EIMS and NMR assignments. See http://www.rsc.org/suppdata/cc/b0/b000711k/

Abstract

Incubation of squalene with the site-directed mutant of Ile261Ala of squalene-hopene cyclase from Alicyclobacillus acidocaldarius afforded multiple triterpenes consisting of tri-, tetra- and penta-cyclic skeletons, together with a final product of hopene, among which the previously unknown 6/6/6/6-fused tetracyclic skeletal compounds, denoted prohopene A and B, are included.

Supplementary files

Article information

Article type
Communication
Submitted
24 Jan 2000
Accepted
08 Feb 2000
First published
29 Feb 2000

Chem. Commun., 2000, 441-442

Unnatural natural triterpenes produced by altering isoleucine into alanine at position 261 in hopene synthase and the importance of having the appropriate bulk size at this position for directing the stereochemical destiny during the polycyclization cascade

T. Hoshino, T. Abe and M. Kouda, Chem. Commun., 2000, 441 DOI: 10.1039/B000711K

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