Asymmetric synthesis of (+)-loline
Abstract
The first asymmetric synthesis of (+)-loline has been achieved in 20 steps from (−)-malic acid by a route incorporating intramolecular hetero-Diels–Alder cycloaddition of an acylnitrosodiene.
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Article information
- Article type
- Communication
- Submitted
- 18 Apr 2000
- Accepted
- 22 May 2000
- First published
- 22 Jun 2000
Chem. Commun., 2000, 1263-1264
Permissions
Asymmetric synthesis of (+)-loline
P. R. Blakemore, V. K. Schulze and J. D. White, Chem. Commun., 2000, 1263 DOI: 10.1039/B003121F
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