Enhanced product selectivity in the Mizoroki–Heck reaction using a supercritical carbon dioxide–liquid biphasic system

Abstract

Arylation of ethylene catalysed by Pd complexes bearing triphenyl phosphite ligands proceeds efficiently in a scCO₂–liquid biphasic system to give a mixture of arylated products; the selectivity of monoarylated products, styrene derivatives, can be improved by increasing the CO₂ pressure, where the monoarylated products are effectively extracted from the liquid reaction phase into the scCO₂ phase to prevent over-reactions to diarylated products.