A hydrolytically stable sugar phosphonate coupled to a steroid via a long and semi-rigid spacer (synthesized via a 12-step sequence) binds both to the mannose-6-phosphonate receptors of certain cancer cells and to the lipid bilayer of vesicles, thereby serving as a multivalent adhesive between cell and vesicle surfaces.
A mannose-6-phosphonate–cholesterylamine conjugate as a specific molecular adhesive linking cancer cells with vesicles
V. Barragan, F. M. Menger, K. L. Caran, C. Vidil, A. Morère and J. Montero, Chem. Commun., 2001, 85 DOI: 10.1039/B008446H
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