Issue 3, 2001
From the journal:

Chemical Communications

Modified guanidines as chiral superbases: application to asymmetric Michael reaction of glycine imine with acrylate or its related compounds

Tsutomu Ishikawa,*a   Yukari Araki,a   Takuya Kumamoto,a   Hiroko Seki,b   Keiko Fukudac  and  Toshio Isobea  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi, Inage, Chiba, Japan

b Chemical Analysis Center, Chiba University, 1-33 Yayoi, Inage, Chiba, Japan

c Central Research Laboratory, Shiratori Pharmaceutical Co. Ltd., 6-11-24 Tsudanuma, Narashino, Chiba, Japan

Abstract

Modified guanidines efficiently catalysed the asymmetric Michael reaction of a prochiral glycine derivative with acrylate or its related compounds either in solution or without a solvent under simple and mild conditions (>95% ee).

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Article information

DOI
https://doi.org/10.1039/B009193F
Article type
Communication
Submitted
16 Nov 2000
Accepted
13 Dec 2000
First published
18 Jan 2001

Chem. Commun., 2001, 245-246

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Modified guanidines as chiral superbases: application to asymmetric Michael reaction of glycine imine with acrylate or its related compounds

T. Ishikawa, Y. Araki, T. Kumamoto, H. Seki, K. Fukuda and T. Isobe, Chem. Commun., 2001, 245 DOI: 10.1039/B009193F

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