Synthesis of novel non-cross-linking pyrrolobenzodiazepines with remarkable DNA binding affinity and potent antitumour activity

Ahmed Kamal; N. Laxman; G. Ramesh; K. Neelima; Anand K. Kondapi

doi:10.1039/B009195M

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Synthesis of novel non-cross-linking pyrrolobenzodiazepines with remarkable DNA binding affinity and potent antitumour activity

Ahmed Kamal,*^a N. Laxman,^a G. Ramesh,^a K. Neelima^b and Anand K. Kondapi^b

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* Corresponding authors

^a Division of Organic Chemistry, Indian Institute of Chemical Technology, 500 007, Hyderabad, India.
E-mail: ahmedkamal@iict.ap.nic.in

^b Department of Biochemistry, School of Life Sciences, University of Hyderabad, 500 046, Hyderabad, India

Abstract

Mixed imine–amide pyrrolobenzodiazepine dimers have been prepared which exhibit potent antitumour activity and have significant DNA binding affinity; one of them, 1c, has been shown to cause a remarkable rise in the melting temperature of calf thymus DNA.

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Correction HTM (2K)

Article information

DOI: https://doi.org/10.1039/B009195M
Article type: Communication
Submitted: 16 Nov 2000
Accepted: 23 Jan 2001
First published: 13 Feb 2001

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Chem. Commun., 2001, 437-438

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Synthesis of novel non-cross-linking pyrrolobenzodiazepines with remarkable DNA binding affinity and potent antitumour activity

A. Kamal, N. Laxman, G. Ramesh, K. Neelima and A. K. Kondapi, Chem. Commun., 2001, 437 DOI: 10.1039/B009195M

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Chemical Communications

Synthesis of novel non-cross-linking pyrrolobenzodiazepines with remarkable DNA binding affinity and potent antitumour activity

Abstract

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Synthesis of novel non-cross-linking pyrrolobenzodiazepines with remarkable DNA binding affinity and potent antitumour activity

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