Synthesis and biological evaluation of aPtdIns(3,4,5)P3 affinity matrix

Gavin F. Painter; Jan. W. Thuring; Ze-Yi Lim; Andrew B. Holmes; Phillip T. Hawkins; Leonard R. Stephens

doi:10.1039/B101320N

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Synthesis and biological evaluation of a PtdIns(3,4,5)P₃ affinity matrix

Gavin F. Painter,^ab Jan. W. Thuring,^ab Ze-Yi Lim,^a Andrew B. Holmes,*^ab Phillip T. Hawkins^c and Leonard R. Stephens^c

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* Corresponding authors

^a Cambridge Centre for Molecular Recognition, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: abh1@cam.ac.uk
Fax: +44 1223 336362
Tel: +44 1223 336404

^b Melville Laboratory, Department of Chemistry, University of Cambridge, Pembroke Street, Cambridge, UK
E-mail: abhl@cam.ac.uk
Fax: +44 1223 334866
Tel: +44 1223 334370

^c Babraham Institute, Department of Signalling, Inositide Laboratory, Cambridge, UK

Abstract

New PtdIns(3,4,5)P₃ binding proteins have been identified utilising PtdIns(3,4,5)P₃ modified affinity matrix 1 which was synthesised from myo-inositol derivative 2, phosphoramidite 9 and an agarose based solid support.

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Article information

DOI: https://doi.org/10.1039/B101320N
Article type: Communication
Submitted: 09 Feb 2001
Accepted: 27 Feb 2001
First published: 20 Mar 2001

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Chem. Commun., 2001, 645-646

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Synthesis and biological evaluation of a PtdIns(3,4,5)P₃ affinity matrix

G. F. Painter, Jan. W. Thuring, Z. Lim, A. B. Holmes, P. T. Hawkins and L. R. Stephens, Chem. Commun., 2001, 645 DOI: 10.1039/B101320N

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