Issue 12, 2002
From the journal:

Chemical Communications

5,5-Fused thiophene γ-lactams as templates for serine protease inhibition

Marie E. Migaud,a   Rupert C. Wilmouth,a   Gary I. Mills,b   Gareth J. Wayne,b   Catherine Risley,b   Christopher Chambers,b   Simon J. F. Macdonaldc  and  Christopher J. Schofield*a  

* Corresponding authors

a The Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory, South Parks Road, Oxford, UK
E-mail: christopher.schofield@chem.ox.ac.uk
Fax: +44 (0)1865 275674
Tel: +44 (0)1865 275625

b Receptor and Enzyme Screening Technology, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, UK

c Medicinal Chemistry 1, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, UK

Abstract

Novel 5,5-fused thiophene lactams are potent inhibitors and acylating agents of HNE and PPE.

Graphical abstract: 5,5-Fused thiophene γ-lactams as templates for serine protease inhibition

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Article information

DOI
https://doi.org/10.1039/B111627D
Article type
Communication
Submitted
21 Dec 2001
Accepted
08 Apr 2002
First published
10 May 2002

Chem. Commun., 2002, 1274-1275

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5,5-Fused thiophene γ-lactams as templates for serine protease inhibition

M. E. Migaud, R. C. Wilmouth, G. I. Mills, G. J. Wayne, C. Risley, C. Chambers, S. J. F. Macdonald and C. J. Schofield, Chem. Commun., 2002, 1274 DOI: 10.1039/B111627D

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