Issue 11, 2002
From the journal:

Chemical Communications

A novel dizinc bridged hydroxamate model for hydroxamate inhibited zinc hydrolases†

David A. Brown,*a   William Errington,b   Noel J. Fitzpatrick,a   William K. Glass,a   Terence J. Kemp,b   Hassan Nimira  and  Áine T. Ryana  

* Corresponding authors

a Department of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland
E-mail: noel.fitzpatrick@ucd.ie;

b Department of Chemistry, University of Warwick, Coventry, UK
E-mail: w.errington@warwick.ac.uk

Abstract

Reaction of Zn(OAc)2·2H2O with tmen leads to the formation of [Zn(tmen)(OAc)2] (I) which reacts with benzohydroxamic acid to form Zn(BA)2·H2O (II) and the novel dizinc hydroxamate bridged complex [Zn2(μ-OAc)2(OAc)(μ-BA)(tmen)] (III), which may also be prepared by self-assembly and whose structure closely mimics that of the native hydroxamate inhibited Aeromonas proteolytica aminopeptidase.

Graphical abstract: A novel dizinc bridged hydroxamate model for hydroxamate inhibited zinc hydrolases

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Article information

DOI
https://doi.org/10.1039/B202612K
Article type
Communication
Submitted
15 Mar 2002
Accepted
18 Apr 2002
First published
02 May 2002

Chem. Commun., 2002, 1210-1211

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A novel dizinc bridged hydroxamate model for hydroxamate inhibited zinc hydrolases

D. A. Brown, W. Errington, N. J. Fitzpatrick, W. K. Glass, T. J. Kemp, H. Nimir and Á. T. Ryan, Chem. Commun., 2002, 1210 DOI: 10.1039/B202612K

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