The one-pot three-component condensation of a β-ketoester, ammonia and an alkynone in the presence of a Brønsted or Lewis acid or Amberlyst 15 ion exchange resin provided 2,3,6-trisubstituted or 2,3,4,6-tetrasubstituted pyridines directly in good yield and with total regiocontrol.
M. C. Bagley, J. W. Dale and J. Bower, Chem. Commun., 2002, 1682 DOI: 10.1039/B203900A
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