Issue 17, 2002
From the journal:

Chemical Communications

3′,4′-trans-Linked bicyclic nucleosides locked in S-type conformations

Helena Thomasen,a   Michael Meldgaard,b   Morten Freitag,a   Michael Petersen,a   Jesper Wengela  and  Poul Nielsen*a  

* Corresponding authors

a Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK-5230, Odense M, Denmark
E-mail: pon@chem.sdu.dk

b Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100, Copenhagen, Denmark

Abstract

A novel class of 3′,4′-trans-linked bicyclic nucleosides with locked S-type furanose conformations is introduced by synthesis of two model derivatives; one was obtained by cyclic ether formation and the other by ring-closing metathesis methodology.

Graphical abstract: 3′,4′-trans-Linked bicyclic nucleosides locked in S-type conformations

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Article information

DOI
https://doi.org/10.1039/B205031E
Article type
Communication
Submitted
24 May 2002
Accepted
04 Jul 2002
First published
12 Aug 2002

Chem. Commun., 2002, 1888-1889

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3′,4′-trans-Linked bicyclic nucleosides locked in S-type conformations

H. Thomasen, M. Meldgaard, M. Freitag, M. Petersen, J. Wengel and P. Nielsen, Chem. Commun., 2002, 1888 DOI: 10.1039/B205031E

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