Issue 17, 2002
From the journal:

Chemical Communications

Tandem enzyme-catalysed oxidations of alkyl phenyl sulfides and alkyl benzenes: enantiocomplementary routes to chiral phenols

Derek R. Boyd,*ab   Narain D. Sharma,a   Vera Ljubez,a   Breige E. Byrne,a   Steven D. Shepherd,a   Christopher C. R. Allen,b   Leonid A. Kulakov,bc   Michael J. Larkinb  and  Howard Daltond  

* Corresponding authors

a School of Chemistry, The Queen′s University of Belfast, Belfast, UK
E-mail: dr.boyd@qub.ac.uk

b QUESTOR Centre, The Queen′s University of Belfast, Belfast, UK

c School of Biology and Biochemistry, The Queen′s University of Belfast, Belfast, UK

d Department of Biological Sciences, The University of Warwick, Coventry, UK

Abstract

Dioxygenase-catalysed trioxygenation of alkyl phenyl sulfides and alkyl benzenes yields enantiopure cis-dihydrodiol sulfoxides and triols respectively; naphthalene cis-dihydrodiol dehydrogenase-catalysed aromatisation of these diastereoisomers gives enantiopure catechols of either configuration.

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Article information

DOI
https://doi.org/10.1039/B205903G
Article type
Communication
Submitted
19 Jun 2002
Accepted
09 Jul 2002
First published
29 Jul 2002

Chem. Commun., 2002, 1914-1915

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Tandem enzyme-catalysed oxidations of alkyl phenyl sulfides and alkyl benzenes: enantiocomplementary routes to chiral phenols

D. R. Boyd, N. D. Sharma, V. Ljubez, B. E. Byrne, S. D. Shepherd, C. C. R. Allen, L. A. Kulakov, M. J. Larkin and H. Dalton, Chem. Commun., 2002, 1914 DOI: 10.1039/B205903G

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