Issue 1, 2003

Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride

Abstract

Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride in pyridine produced adenosine 5′-phosphoramidates in good yields under mild conditions, it is interesting that nucleophilic attack of amino acid methyl esters only occurred on α-phosphorus of ADP.

Graphical abstract: Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride

Article information

Article type
Communication
Submitted
15 Aug 2002
Accepted
22 Nov 2002
First published
02 Dec 2002

Chem. Commun., 2003, 134-135

Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride

H. Fu, B. Han and Y. Zhao, Chem. Commun., 2003, 134 DOI: 10.1039/B207992E

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