Issue 1, 2003
From the journal:

Chemical Communications

The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug†

Murray S. Davies,ac   Susan J. Berners-Price,*a   John W. Coxb  and  Nicholas Farrell*b  

* Corresponding authors

a Department of Chemistry, University of Western Australia, Crawley, WA, Australia
E-mail: sbp@chem.uwa.edu.au
Fax: 61-8 9380 1005
Tel: 61-8-9380-3258

b Department of Chemistry, Virginia Commonwealth University, Richmond, VA, USA
E-mail: nfarrell@saturn.vcu.edu
Fax: 1-804-828-8599
Tel: 1-804-828-6320

c School of Pharmacy and Molecular Sciences, James Cook University, Townsville, QLD, Australia

Abstract

The rate of aquation of a dinuclear platinum anticancer agent is altered in the presence of template DNA with enhancement of hydrolysis in the presence of single-stranded over double-stranded DNA, emphasising how the alteration of chemical properties of small molecules in the presence of large host interactions is also dependent on the conformation and nature of that host.

Graphical abstract: The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug

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Article information

DOI
https://doi.org/10.1039/B209661G
Article type
Communication
Submitted
03 Oct 2002
Accepted
18 Nov 2002
First published
29 Nov 2002

Chem. Commun., 2003, 122-123

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The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug

M. S. Davies, S. J. Berners-Price, J. W. Cox and N. Farrell, Chem. Commun., 2003, 122 DOI: 10.1039/B209661G

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