Issue 5, 2003

Asymmetric protonation of lithium enolates of α-amino acid derivatives with α-amino acid-based chiral Brønsted acids

Abstract

The reaction of lithium enolates of α-amino acid derivatives with chiral amides, easily synthesized from L-tert-leucine, gives corresponding optically active unnatural α-amino acid derivatives with up to 87% ee.

Graphical abstract: Asymmetric protonation of lithium enolates of α-amino acid derivatives with α-amino acid-based chiral Brønsted acids

Supplementary files

Article information

Article type
Communication
Submitted
18 Nov 2002
Accepted
07 Jan 2003
First published
30 Jan 2003

Chem. Commun., 2003, 566-567

Asymmetric protonation of lithium enolates of α-amino acid derivatives with α-amino acid-based chiral Brønsted acids

K. Futatsugi, A. Yanagisawa and H. Yamamoto, Chem. Commun., 2003, 566 DOI: 10.1039/B211523A

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