Issue 5, 2003
From the journal:

Chemical Communications

The levelling effect of solvational imbalances in the reactions of oximate α-nucleophiles with electrophilic phosphorus centers. Relevance to detoxification of organophosphorus esters

F. Terrier,*a   E. Le Guével,a   A. P. Chatrousse,a   G. Moutiersa  and  E. Buncel*b  

* Corresponding authors

a Laboratoire SIRCOB, UMR 8086, Institut Lavoisier-Franklin, Université de Versailles, 45 Avenue des Etats-Unis 78035, Versailles Cedex, France

b Department of Chemistry, Queen’s University, Kingston, Ontario, Canada

Abstract

A study of the reactions of oximate α-nucleophiles with diisopropylphosphorofluoridate (DFP) and two model phosphonates, has revealed either a levelling-off in reactivity or a bell-shaped behaviour in accordance with a critical decoupling of desolvation and bond formation (solvational imbalances); the relevance of these results to detoxification is emphasized.

Graphical abstract: The levelling effect of solvational imbalances in the reactions of oximate α-nucleophiles with electrophilic phosphorus centers. Relevance to detoxification of organophosphorus esters

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Article information

DOI
https://doi.org/10.1039/B212160N
Article type
Communication
Submitted
06 Dec 2002
Accepted
23 Jan 2003
First published
04 Feb 2003

Chem. Commun., 2003, 600-601

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The levelling effect of solvational imbalances in the reactions of oximate α-nucleophiles with electrophilic phosphorus centers. Relevance to detoxification of organophosphorus esters

F. Terrier, E. Le Guével, A. P. Chatrousse, G. Moutiers and E. Buncel, Chem. Commun., 2003, 600 DOI: 10.1039/B212160N

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