Issue 8, 2003
From the journal:

Chemical Communications

Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidases†

Annabelle Varrot,a   James Macdonald,b   Robert V. Stick,b   Gavin Pell,c   Harry J. Gilbertc  and  Gideon J. Davies*a  

* Corresponding authors

a Structural Biology Laboratory, Department of Chemistry, The University of York, Heslington, UK
E-mail: davies@ysbl.york.ac.uk
Fax: 44 1904 328266
Tel: 44 1904 328260

b School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley WA 6009, Australia
E-mail: rvs@chem.uwa.edu.au
Fax: 61 8 9380 3993
Tel: 61 8 9380 3200

c School of Cell and Molecular Biosciences, University of Newcastle upon Tyne, The Agriculture Building, Newcastle upon Tyne, UK
E-mail: H.J.Gilbert@ncl.ac.uk
Fax: 44 191 222 8684
Tel: 44 191 222 6962

Abstract

A cellobio-derived isofagomine glycosidase inhibitor (Ki ∼ 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.

Graphical abstract: Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidases

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Article information

DOI
https://doi.org/10.1039/B301592K
Article type
Communication
Submitted
11 Feb 2003
Accepted
06 Mar 2003
First published
20 Mar 2003

Chem. Commun., 2003, 946-947

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Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidases

A. Varrot, J. Macdonald, R. V. Stick, G. Pell, H. J. Gilbert and G. J. Davies, Chem. Commun., 2003, 946 DOI: 10.1039/B301592K

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