Issue 12, 2003
From the journal:

Chemical Communications

Application of an ephedrine chiral linker in a solid-phase, ‘asymmetric catch-release’ approach to γ-butyrolactones

Nessan J. Kerrigan,a   Panee C. Hutchison,a   Tom D. Heightmanb  and  David J. Procter*a  

* Corresponding authors

a Department of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow, Scotland, UK
E-mail: davidp@chem.gla.ac.uk

b GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex, UK

Abstract

A Sm(II)-mediated, asymmetric, intermolecular ketyl-olefin addition employing α,β-unsaturated esters linked to resin through an ephedrine ‘chiral link’ has been applied in a direct ‘asymmetric catch-release’ approach to γ-butyrolactones.

Graphical abstract: Application of an ephedrine chiral linker in a solid-phase, ‘asymmetric catch-release’ approach to γ-butyrolactones

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Article information

DOI
https://doi.org/10.1039/B302471G
Article type
Communication
Submitted
05 Mar 2003
Accepted
11 Apr 2003
First published
13 May 2003

Chem. Commun., 2003, 1402-1403

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Application of an ephedrine chiral linker in a solid-phase, ‘asymmetric catch-release’ approach to γ-butyrolactones

N. J. Kerrigan, P. C. Hutchison, T. D. Heightman and D. J. Procter, Chem. Commun., 2003, 1402 DOI: 10.1039/B302471G

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