Issue 7, 2004
From the journal:

Chemical Communications

cis-Cyclopentyl PNA (cpPNA) as constrained chiral PNA analogues: stereochemical dependence of DNA/RNA hybridization†

T. Govindaraju,a   Vaijayanti A. Kumar*a  and  Krishna N. Ganesh*a  

* Corresponding authors

a Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune, India
E-mail: kng@ems.ncl.res.in
Fax: 91 20 589 3153

Abstract

DNA/RNA hybridization studies of PNA-T oligomers with cis-(1S,2R/1R,2S)-cyclopentyl units in the backbone show stereochemistry dependent binding with RNA/DNA discrimination.

Graphical abstract: cis-Cyclopentyl PNA (cpPNA) as constrained chiral PNA analogues: stereochemical dependence of DNA/RNA hybridization

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Article information

DOI
https://doi.org/10.1039/B317000D
Article type
Communication
Submitted
06 Jan 2004
Accepted
09 Feb 2004
First published
02 Mar 2004

Chem. Commun., 2004, 860-861

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cis-Cyclopentyl PNA (cpPNA) as constrained chiral PNA analogues: stereochemical dependence of DNA/RNA hybridization

T. Govindaraju, V. A. Kumar and K. N. Ganesh, Chem. Commun., 2004, 860 DOI: 10.1039/B317000D

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