Dynamic kinetic resolution: an efficient route to anti				α-amino-β-hydroxy esters via Ru-SYNPHOS® catalyzed hydrogenation

Céline Mordant; Pascal Dünkelmann; Virginie Ratovelomanana-Vidal; Jean-Pierre Genet

doi:10.1039/B401631A

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Dynamic kinetic resolution: an efficient route to anti α-amino-β-hydroxy estersvia Ru-SYNPHOS^® catalyzed hydrogenation†

Céline Mordant,^a Pascal Dünkelmann,^a Virginie Ratovelomanana-Vidal*^a and Jean-Pierre Genet*^a

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* Corresponding authors

^a Laboratoire de Synthèse Sélective Organique et Produits Naturels, UMR 7573 C.N.R.S., Ecole Nationale Supérieure de Chimie de Paris, 11, rue P. et M. Curie, 75231 Paris Cedex 05, France
E-mail: genet@ext.jussieu.fr, gvidal@ext.jussieu.fr
Fax: +33 (0)1 4407 1062
Tel: +33 (0)1 4427 6744

Abstract

The Ru(II)-catalyzed hydrogenation of α-amino-β-keto esters as their hydrochloride salts affords preparation of the corresponding anti α-amino-β-hydroxy esters under mild conditions with high diastereoselectivities and enantioselectivities via dynamic kinetic resolution.

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Supplementary files

Experimental details for the preparation of compounds 1?4 PDF (240K)

Article information

DOI: https://doi.org/10.1039/B401631A
Article type: Communication
Submitted: 03 Feb 2004
Accepted: 31 Mar 2004
First published: 06 May 2004

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Chem. Commun., 2004, 1296-1297

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Dynamic kinetic resolution: an efficient route to anti α-amino-β-hydroxy esters via Ru-SYNPHOS^® catalyzed hydrogenation

C. Mordant, P. Dünkelmann, V. Ratovelomanana-Vidal and J. Genet, Chem. Commun., 2004, 1296 DOI: 10.1039/B401631A

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