Issue 20, 2004
From the journal:

Chemical Communications

A regioregular polyalkylthiophene bearing covalently-linked biotin, and its interaction with avidin in solution and in thin films†

Fouzi Mouffouk,a   Simon J. Higgins,*a   Stewart J. Brown,a   Naser Sedghi,b   Bill Ecclestonb  and  Stuart Reemanc  

* Corresponding authors

a Department of Chemistry, University of Liverpool, Crown Street, Liverpool, UK

b Department of Electrical and Electronic Engineering, University of Liverpool, Brownlow Hill, Liverpool, UK

c Dstl Chemical and Biological Sciences, Salisbury, UK

Abstract

A regioregular copolymer of 3-hexylthiophene and 3-(6-hydroxyhex-1-yl)thiophene has been functionalised with biotin hydrazide; binding of avidin to the biotin moieties causes drastic changes to the absorption spectrum of the polymer in solution, and to the electrochemistry and conductivity of the polymer in thin films.

Graphical abstract: A regioregular polyalkylthiophene bearing covalently-linked biotin, and its interaction with avidin in solution and in thin films

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Article information

DOI
https://doi.org/10.1039/B408935A
Article type
Communication
Submitted
14 Jun 2004
Accepted
30 Jul 2004
First published
06 Sep 2004

Chem. Commun., 2004, 2314-2315

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A regioregular polyalkylthiophene bearing covalently-linked biotin, and its interaction with avidin in solution and in thin films

F. Mouffouk, S. J. Higgins, S. J. Brown, N. Sedghi, B. Eccleston and S. Reeman, Chem. Commun., 2004, 2314 DOI: 10.1039/B408935A

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