Starting from a vinylepoxide, a short and practical synthesis of D-erythro-sphingosine is described. The key transformations are a regioselective opening of the vinylepoxide and an E-selective cross-metathesis, affording the target molecule in 5 steps and 51% overall yield.
S. Torssell and P. Somfai, Org. Biomol. Chem., 2004, 2, 1643 DOI: 10.1039/B403568B
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