Issue 9, 2005
From the journal:

Chemical Communications

Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster†

Sian M. Cooper,b   Russell J. Cox,a   John Crosby,a   Matthew P. Crump,a   Joanne Hothersall,b   Wanpen Laosripaiboon,a   Thomas J. Simpson*a  and  Christopher M. Thomasb  

* Corresponding authors

a School of Chemistry, University of Bristol, Cantock’s Close, Bristol, UK
E-mail: tom.simpson@bris.ac.uk
Fax: +44 (0)117 9298611

b School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK

Abstract

Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.

Graphical abstract: Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

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Article information

DOI
https://doi.org/10.1039/B414781B
Article type
Communication
Submitted
23 Sep 2004
Accepted
24 Nov 2004
First published
17 Jan 2005

Chem. Commun., 2005, 1179-1181

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Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

S. M. Cooper, R. J. Cox, J. Crosby, M. P. Crump, J. Hothersall, W. Laosripaiboon, T. J. Simpson and C. M. Thomas, Chem. Commun., 2005, 1179 DOI: 10.1039/B414781B

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