Issue 15, 2005
From the journal:

Chemical Communications

Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages†

Julien Leclaire,a   Laurent Vial,a   Sijbren Otto*a  and  Jeremy K. M. Sanders*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: so230@cam.ac.uk, jkms@cam.ac.uk
Fax: +44 1223 336017
Tel: +44 1223 336411

Abstract

Dynamic combinatorial libraries have been prepared which feature two simultaneous covalent exchange reactions in aqueous solution at neutral pH. This allows for diversity, not only of the subunits that are linked, but also of the linkage itself.

Graphical abstract: Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages

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Article information

DOI
https://doi.org/10.1039/B500638D
Article type
Communication
Submitted
14 Jan 2005
Accepted
09 Feb 2005
First published
18 Feb 2005

Chem. Commun., 2005, 1959-1961

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Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages

J. Leclaire, L. Vial, S. Otto and J. K. M. Sanders, Chem. Commun., 2005, 1959 DOI: 10.1039/B500638D

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