Issue 30, 2005

Sterically-controlled regioselective para-substitutions of aniline

Abstract

Introduction of sterically demanding 1-isopropyl-2-methylpropyl or triisopropylsilyl groups at the nitrogen of aniline allows high-yielding regioselective para-substitution to be achieved using a lithiation/substitution sequence.

Graphical abstract: Sterically-controlled regioselective para-substitutions of aniline

Supplementary files

Article information

Article type
Communication
Submitted
13 May 2005
Accepted
27 May 2005
First published
24 Jun 2005

Chem. Commun., 2005, 3835-3837

Sterically-controlled regioselective para-substitutions of aniline

P. W. Dyer, J. Fawcett, G. A. Griffith, M. J. Hanton, C. Olivier, A. R. Patterson and S. Suhard, Chem. Commun., 2005, 3835 DOI: 10.1039/B506824J

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