Issue 38, 2005
From the journal:

Chemical Communications

A general and versatile molecular design for host molecules working in water: a duplex-based potassium sensor consisting of three functional regions†

Kazuhisa Fujimoto,*a   Yu Mutoa  and  Masahiko Inouye*ab  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan
E-mail: fujimoto@ms.toyama-mpu.ac.jp
Fax: +81-76-434-5049
Tel: +81-76-434-7526

b PRESTO, Japan Science and Technology Agency (JST), Japan

Abstract

A general and versatile molecular design for host molecules was proposed based on the structural motif of antibodies. A water-soluble potassium sensor was developed by this molecular design, which consists of three functional regions, benzo-15-crown-5 ether, DNA, and pyrene as guest-binding, dimerising, and signaling sites, respectively. The molecular sensor emitted the monomer fluorescence of the pyrene fluorophore predominantly when existing as a random structure, while it formed a duplex upon recognition of K+ to bring about monomer–excimer emission switching.

Graphical abstract: A general and versatile molecular design for host molecules working in water: a duplex-based potassium sensor consisting of three functional regions

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Article information

DOI
https://doi.org/10.1039/B508189K
Article type
Communication
Submitted
10 Jun 2005
Accepted
05 Aug 2005
First published
08 Sep 2005

Chem. Commun., 2005, 4780-4782

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A general and versatile molecular design for host molecules working in water: a duplex-based potassium sensor consisting of three functional regions

K. Fujimoto, Y. Muto and M. Inouye, Chem. Commun., 2005, 4780 DOI: 10.1039/B508189K

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