Issue 3, 2005
From the journal:

Lab on a Chip

Measuring reaction kinetics in a lab-on-a-chip by microcoil NMR

Henk Wensink,a   Fernando Benito-Lopez,b   Dorothee C. Hermes,a   Willem Verboom,b   Han J. G. E. Gardeniers,*a   David N. Reinhoudtb  and  Albert van den Berga  

* Corresponding authors

a BIOS, the Lab-on-a-Chip group, MESA+ Research Institute, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands
E-mail: j.g.e.gardeniers@utwente.nl
Fax: +31 53 4892287
Tel: +31 53 4894356

b Laboratory of Supramolecular Chemistry and Technology, MESA+ Research Institute, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands

Abstract

A microfluidic chip with an integrated planar microcoil was developed for Nuclear Magnetic Resonance (NMR) spectroscopy on samples with volumes of less than a microliter. Real-time monitoring of imine formation from benzaldehyde and aniline in the microreactor chip by NMR was demonstrated. The reaction times in the chip can be set from 30 min down to ca. 2 s, the latter being the mixing time in the microfluidic chip. Design rules will be described to optimize the microreactor and detection coil in order to deal with the inherent sensitivity of NMR and to minimize magnetic field inhomogeneities and obtain sufficient spectral resolution.

Graphical abstract: Measuring reaction kinetics in a lab-on-a-chip by microcoil NMR

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Article information

DOI
https://doi.org/10.1039/B414832K
Article type
Paper
Submitted
24 Sep 2004
Accepted
15 Dec 2004
First published
28 Jan 2005

Lab Chip, 2005,5, 280-284

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Measuring reaction kinetics in a lab-on-a-chip by microcoil NMR

H. Wensink, F. Benito-Lopez, D. C. Hermes, W. Verboom, H. J. G. E. Gardeniers, D. N. Reinhoudt and A. van den Berg, Lab Chip, 2005, 5, 280 DOI: 10.1039/B414832K

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