Issue 4, 2005
From the journal:

Organic & Biomolecular Chemistry

Synthesis and photochemical properties of photoactivated antitumor prodrugs releasing 5-fluorouracil†

Zhouen Zhang,a   Hiroshi Hatta,a   Takeo Itoa  and  Sei-ichi Nishimoto*a  

* Corresponding authors

a Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo-ku, Kyoto, Japan
E-mail: nishimot@scl.kyoto-u.ac.jp

Abstract

A new family of antitumor prodrugs (1–3) of 5-fluorouracil (5-FU) possessing photolabile 2-nitrobenzyl chromophores have been designed and synthesized to investigate the efficiency and mechanism of photoactivated 5-FU release upon UV-irradiation at λex = 365 nm. The photoactivated prodrug 3 derived from conjugation of 2 with a tumor-homing cyclic peptide Cys-Asn-Gly-Arg-Cys (CNGRC) was so designed as to manifest a tumor-targeting function.

Graphical abstract: Synthesis and photochemical properties of photoactivated antitumor prodrugs releasing 5-fluorouracil

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Article information

DOI
https://doi.org/10.1039/B417734G
Article type
Paper
Submitted
24 Nov 2004
Accepted
20 Dec 2004
First published
12 Jan 2005

Org. Biomol. Chem., 2005,3, 592-596

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Synthesis and photochemical properties of photoactivated antitumor prodrugs releasing 5-fluorouracil

Z. Zhang, H. Hatta, T. Ito and S. Nishimoto, Org. Biomol. Chem., 2005, 3, 592 DOI: 10.1039/B417734G

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