Issue 5, 2006
From the journal:

Chemical Communications

Cyclodextrin-based isolation of Ostwald's metastable polymorphs occurring during crystallization

Yoh Sonoda,a   Fumitoshi Hirayama,a   Hidetoshi Arima,a   Yoshihiro Yamaguchi,a   Wolfram Saengerb  and  Kaneto Uekama*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan
E-mail: uekama@gpo.kumamoto-u.ac.jp
Fax: +81-96-371-4420
Tel: +81-96-371-4160

b Institut für Kristallographie, Freie Universität Berlin, Takustrasse 6, Berlin, Germany
E-mail: saenger@chemie.fu-berlin.de
Fax: +30-83856702
Tel: +30-83853412

Abstract

We describe a novel approach for the selective isolation of Ostwald's intermediate metastable polymorphs occurring during an early stage of crystallization, by utilizing the inclusion complex formed with a cyclic oligosaccharide derivative, 2,6-di-O-methyl-β-cyclodextrin.

Graphical abstract: Cyclodextrin-based isolation of Ostwald's metastable polymorphs occurring during crystallization

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Article information

DOI
https://doi.org/10.1039/B515349B
Article type
Communication
Submitted
28 Oct 2005
Accepted
07 Dec 2005
First published
20 Dec 2005

Chem. Commun., 2006, 517-519

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Cyclodextrin-based isolation of Ostwald's metastable polymorphs occurring during crystallization

Y. Sonoda, F. Hirayama, H. Arima, Y. Yamaguchi, W. Saenger and K. Uekama, Chem. Commun., 2006, 517 DOI: 10.1039/B515349B

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