Issue 25, 2006
From the journal:

Chemical Communications

Two-dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex†

Sherri Rinker,a   Yan Liua  and  Hao Yan*a  

* Corresponding authors

a Department of Chemistry & Biochemistry and Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
E-mail: hao.yan@asu.edu
Fax: (+1) 480 727 2378
Tel: (+1) 480-727-8570

Abstract

We measured the helical repeats of a non-natural nucleic acid, locked nucleic acid (LNA), by incorporating LNA strands into the outer arms of a DNA double crossover (DX) molecule; atomic force microscopy (AFM) imaging of the two-dimensional (2D) arrays self-assembled from these DX molecules allows us to derive the helical repeat of the LNA/DNA hetero-duplex to be 13.2 ± 0.9 base pairs per turn.

Graphical abstract: Two-dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex

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Article information

DOI
https://doi.org/10.1039/B603872G
Article type
Communication
Submitted
14 Mar 2006
Accepted
24 Apr 2006
First published
23 May 2006

Chem. Commun., 2006, 2675-2677

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Two-dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex

S. Rinker, Y. Liu and H. Yan, Chem. Commun., 2006, 2675 DOI: 10.1039/B603872G

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