Issue 26, 2006
From the journal:

Chemical Communications

Insertion of two pyrene moieties into oligodeoxyribonucleotides for the efficient detection of deletion polymorphisms†

Hiromu Kashida,a   Hiroyuki Asanuma*bc  and  Makoto Komiyamaa  

* Corresponding authors

a Research Center for Advanced Science and Technology, The University of Tokyo, Komaba, Meguro-ku, Tokyo, Japan

b Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya, Japan
E-mail: asanuma@mol.nagoya-u.ac.jp
Fax: +81-52-789-2528
Tel: +81-52-789-2488

c CREST, Japan Science and Technology Agency (JST), Kawaguchi, Japan

Abstract

For the detection of deletion polymorphisms, two pyrene moieties are tethered to an oligodeoxyribonucleotide (ODN) on both sides of the intervening base; one- and two-base deletions can be selectively detected by the strength of the excimer emission.

Graphical abstract: Insertion of two pyrene moieties into oligodeoxyribonucleotides for the efficient detection of deletion polymorphisms

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Article information

DOI
https://doi.org/10.1039/B604776A
Article type
Communication
Submitted
03 Apr 2006
Accepted
11 May 2006
First published
06 Jun 2006

Chem. Commun., 2006, 2768-2770

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Insertion of two pyrene moieties into oligodeoxyribonucleotides for the efficient detection of deletion polymorphisms

H. Kashida, H. Asanuma and M. Komiyama, Chem. Commun., 2006, 2768 DOI: 10.1039/B604776A

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