Issue 19, 2006

Synthesis and evaluation of potential CT (computer tomography) contrast agents for bone structure and microdamage analysis

Abstract

The design and synthesis of several novel X-ray contrast agents 13, developed for targeting bone structures, and in particularly microcracks in bones, using CT (Computer Tomography) detection is described. These contrast agents are based on the use of the well known triiodobenzene platform, which was conjugated into one or more phenyliminodiacetate moieties, which can be used to ‘lock’ onto bone matrices. Compounds 13 were all tested for their ability to visualise cracks in bone structures (bovine bones) using μ-CT imaging.

Graphical abstract: Synthesis and evaluation of potential CT (computer tomography) contrast agents for bone structure and microdamage analysis

Supplementary files

Article information

Article type
Paper
Submitted
16 May 2006
Accepted
07 Jul 2006
First published
15 Aug 2006

Org. Biomol. Chem., 2006,4, 3611-3617

Synthesis and evaluation of potential CT (computer tomography) contrast agents for bone structure and microdamage analysis

R. Parkesh, W. Gowin, T. C. Lee and T. Gunnlaugsson, Org. Biomol. Chem., 2006, 4, 3611 DOI: 10.1039/B606976B

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