Rapamycin biosynthesis: elucidation of gene product function

Matthew A. Gregory; Hui Hong; Rachel E. Lill; Sabine Gaisser; Hrvoje Petkovic; Lindsey Low; Lesley S. Sheehan; Isabelle Carletti; Sarah J. Ready; Michael J. Ward; Andrew L. Kaja; Alison J. Weston; Iain R. Challis; Peter F. Leadlay; Christine J. Martin; Barrie Wilkinson; Rose M. Sheridan

doi:10.1039/B608813A

Rapamycin biosynthesis: elucidation of gene product function †

Matthew A. Gregory,^a Hui Hong,^b Rachel E. Lill,^a Sabine Gaisser,^a Hrvoje Petkovic,^a Lindsey Low,^a Lesley S. Sheehan,^a Isabelle Carletti,^a Sarah J. Ready,^a Michael J. Ward,^a Andrew L. Kaja,^a Alison J. Weston,^a Iain R. Challis,^a Peter F. Leadlay,^c Christine J. Martin,^a Barrie Wilkinson^a and Rose M. Sheridan*^a

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^a Biotica, Chesterford Research Park, Little Chesterford, UK
E-mail: rose.sheridan@biotica.com
Fax: +44 (0)1799 532920
Tel: +44 (0)1799 532925

^b Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

^c Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, UK

Abstract

The function of gene products involved in the biosynthesis of the clinically important polyketide rapamycin were elucidated by biotransformation and gene complementation

Organic & Biomolecular Chemistry

Rapamycin biosynthesis: elucidation of gene product function †

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Rapamycin biosynthesis: elucidation of gene product function

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