Issue 19, 2006
From the journal:

Organic & Biomolecular Chemistry

Asymmetric hydrogenation with antibody-achiral rhodium complex†

Hiroyasu Yamaguchi,a   Tohko Hirano,a   Hideaki Kiminami,a   Daisuke Tauraa  and  Akira Harada*a  

* Corresponding authors

a Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan
E-mail: harada@chem.sci.osaka-u.ac.jp
Fax: +81-6-6850-5445
Tel: +81-6-6850-5445

Abstract

Monoclonal antibodies have been elicited against an achiral rhodium complex and this complex was used in the presence of a resultant antibody, 1G8, for the catalytic hydrogenation of 2-acetamidoacrylic acid to produce N-acetyl-L-alanine in high (>98%) enantiomeric excess.

Graphical abstract: Asymmetric hydrogenation with antibody-achiral rhodium complex

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Article information

DOI
https://doi.org/10.1039/B609242J
Article type
Communication
Submitted
29 Jun 2006
Accepted
14 Aug 2006
First published
25 Aug 2006

Org. Biomol. Chem., 2006,4, 3571-3573

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Asymmetric hydrogenation with antibody-achiral rhodium complex

H. Yamaguchi, T. Hirano, H. Kiminami, D. Taura and A. Harada, Org. Biomol. Chem., 2006, 4, 3571 DOI: 10.1039/B609242J

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