Issue 12, 2007
From the journal:

Chemical Communications

Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide–alkyne cycloaddition†

Duane E. Prasuhn, Jr.,a   Robert M. Yeh,a   Andre Obenaus,b   Marianne Manchesterc  and  M. G. Finn*a  

* Corresponding authors

a Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA
E-mail: mgfinn@scripps.edu
Fax: 01-858-784-8850
Tel: 01-858-784-8845

b Non Invasive Imaging laboratory, Loma Linda University, Loma Linda, CA, USA

c Department of Cell Biology, The Scripps Research Institute

Abstract

Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azide–alkyne cycloaddition (CuAAC) and/or with Gd3+ ions by coordination to the viral nucleoprotein show increased T1 relaxivity relative to free Gd(DOTA) complexes in solution.

Graphical abstract: Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide–alkyne cycloaddition

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Article information

DOI
https://doi.org/10.1039/B615084E
Article type
Communication
Submitted
17 Oct 2006
Accepted
14 Dec 2006
First published
15 Jan 2007

Chem. Commun., 2007, 1269-1271

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Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide–alkyne cycloaddition

D. E. Prasuhn, Jr., R. M. Yeh, A. Obenaus, M. Manchester and M. G. Finn, Chem. Commun., 2007, 1269 DOI: 10.1039/B615084E

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