First hypervalent iodine(iii)-catalyzed C–N bond forming reaction: catalytic spirocyclization of amides to N-fused spirolactams

Abstract

A protic solvent, 2,2,2-trifluoroethanol (CF₃CH₂OH), was successfully introduced into hypervalent iodine(III)-involved catalytic cycles as an effective solvent, and the first iodoarene-catalyzed intramolecular carbon–nitrogen bond forming reaction was achieved under strong acid-free and mild conditions.