Issue 24, 2007
From the journal:

Chemical Communications

A catalytic asymmetric protocol for the enantioselective synthesis of 3(2H)-furanones†

Charles M. Marson,*a   Esra Edaan,a   James M. Morrell,a   Simon J. Coles,b   Michael B. Hursthouseb  and  David T. Daviesc  

* Corresponding authors

a Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London, UK
E-mail: c.m.marson@ucl.ac.uk
Fax: +(44) (0)207 679 7463
Tel: +(44) (0)207 679 4712

b Department of Chemistry, EPSRC National Crystallographic Service, Southampton, Hants, UK
E-mail: mbh@soton.ac.uk

c Department of Medicinal Chemistry, GlaxoSmithKline, Gunnels Wood Road, Stevenage, UK

Abstract

3(2H)-Furanones can be prepared by a catalytic asymmetric protocol from enynones, which, if electron-rich, require only one reagent and involve two reactions in a single operation—a domino process.

Graphical abstract: A catalytic asymmetric protocol for the enantioselective synthesis of 3(2H)-furanones

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Article information

DOI
https://doi.org/10.1039/B701548H
Article type
Communication
Submitted
01 Feb 2007
Accepted
27 Feb 2007
First published
26 Mar 2007

Chem. Commun., 2007, 2494-2496

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A catalytic asymmetric protocol for the enantioselective synthesis of 3(2H)-furanones

C. M. Marson, E. Edaan, J. M. Morrell, S. J. Coles, M. B. Hursthouse and D. T. Davies, Chem. Commun., 2007, 2494 DOI: 10.1039/B701548H

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