Issue 5, 2007

Enhanced detection of the pathogenic prion protein by its supramolecular association with para-sulfonato-calix[n]arene derivatives

Abstract

The supramolecular interaction between the pathogenic form of the prion protein and derivatives of the para-sulfonato-calix[n]arenes has been demonstrated and two putative binding sites determined; this interaction leads to an amplification of the Western Blot immunological detection of the prion protein by the SAF84 antibody.

Graphical abstract: Enhanced detection of the pathogenic prion protein by its supramolecular association with para-sulfonato-calix[n]arene derivatives

Article information

Article type
Paper
Submitted
25 Oct 2006
Accepted
09 Jan 2007
First published
15 Feb 2007

New J. Chem., 2007,31, 711-717

Enhanced detection of the pathogenic prion protein by its supramolecular association with para-sulfonato-calix[n]arene derivatives

A. W. Coleman, F. Perret, S. Cecillon, A. Moussa, A. Martin, M. Dupin and H. Perron, New J. Chem., 2007, 31, 711 DOI: 10.1039/B615523P

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