Issue 19, 2007
From the journal:

Organic & Biomolecular Chemistry

Synthesis and biochemical evaluation of O-acetyl-ADP-ribose and N-acetyl analogs†

Lindsay R. Comstocka  and  John M. Denu*a  

* Corresponding authors

a Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, USA
E-mail: jmdenu@wisc.edu
Fax: +1 (608) 262-5253
Tel: +1 (608)265-1859

Abstract

Synthetic routes for the preparation of O-acetyl-ADP-ribose and two novel non-hydrolyzable analogs containing an N-acetyl are described and shown to interact with the macro domain of histone protein H2A1.1.

Graphical abstract: Synthesis and biochemical evaluation of O-acetyl-ADP-ribose and N-acetyl analogs

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Article information

DOI
https://doi.org/10.1039/B710231C
Article type
Communication
Submitted
05 Jul 2007
Accepted
21 Aug 2007
First published
04 Sep 2007

Org. Biomol. Chem., 2007,5, 3087-3091

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Synthesis and biochemical evaluation of O-acetyl-ADP-ribose and N-acetyl analogs

L. R. Comstock and J. M. Denu, Org. Biomol. Chem., 2007, 5, 3087 DOI: 10.1039/B710231C

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