Issue 5, 2008

Construction of macrocyclic thiodepsipeptides: synthesis of a nosiheptide ‘southern hemisphere’ model system

Abstract

A 20-membered macrocyclic thiodepsipeptide has been synthesized as a model for the southern hemisphere of nosiheptide, the key steps being assembly of an acyclic precursor by amide coupling of indole and thiazole fragments followed by formation of the thiolactone in the macrocyclization step.

Graphical abstract: Construction of macrocyclic thiodepsipeptides: synthesis of a nosiheptide ‘southern hemisphere’ model system

Supplementary files

Article information

Article type
Communication
Submitted
10 Oct 2007
Accepted
15 Nov 2007
First published
23 Nov 2007

Chem. Commun., 2008, 591-593

Construction of macrocyclic thiodepsipeptides: synthesis of a nosiheptide ‘southern hemisphere’ model system

M. C. Kimber and C. J. Moody, Chem. Commun., 2008, 591 DOI: 10.1039/B715644H

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