Issue 10, 2008
From the journal:

Chemical Communications

An efficient enantioselective method for asymmetric Michael addition of nitroalkanes to α,β-unsaturated aldehydes†

Yongcan Wang,a   Pengfei Li,a   Xinmiao Liang,*ab   Tony Y. Zhangc  and  Jinxing Ye*b  

* Corresponding authors

a Dalian Institute of Chemical Physics, Chinese Academy of Science, 457 Zhongshan Road, Dalian 116023, China
E-mail: liangxm@dicp.ac.cn

b School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
E-mail: yejx@ecust.edu.cn

c Eli Lilly and Company, Indianapolis, USA

Abstract

The addition of nitroalkanes to α,β-unsaturated aldehydes under the catalysis of (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine and lithium acetate as additive afforded γ-nitroaldehydes in good yield and up to 97% ee.

Graphical abstract: An efficient enantioselective method for asymmetric Michael addition of nitroalkanes to α,β-unsaturated aldehydes

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Article information

DOI
https://doi.org/10.1039/B717000A
Article type
Communication
Submitted
02 Nov 2007
Accepted
11 Jan 2008
First published
31 Jan 2008

Chem. Commun., 2008, 1232-1234

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An efficient enantioselective method for asymmetric Michael addition of nitroalkanes to α,β-unsaturated aldehydes

Y. Wang, P. Li, X. Liang, T. Y. Zhang and J. Ye, Chem. Commun., 2008, 1232 DOI: 10.1039/B717000A

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