Decelerated chirality interconversion of an optically inactive 310-helical peptide by metal chelation

Naoki Ousaka; Norihiko Tani; Ryo Sekiya; Reiko Kuroda

doi:10.1039/B803080D

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Decelerated chirality interconversion of an optically inactive 3₁₀-helical peptide by metal chelation†

Naoki Ousaka,*^a Norihiko Tani,^b Ryo Sekiya^b and Reiko Kuroda*^ab

Author affiliations

* Corresponding authors

^a Japan Science and Technology Agency, ERATO-SORST Kuroda Chiromorphology Team, 4-7-6, Komaba, Meguro-ku, Tokyo, Japan
E-mail: ousaka@chiromor2.erato.rcast.u-tokyo.ac.jp
Fax: (+81) 3 5454 6601

^b Department of Life Science, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo, Japan
E-mail: ckuroda@mail.ecc.u-tokyo.ac.jp
Fax: (+81) 3 5454 6600

Abstract

A dynamically optically inactive 3₁₀-helical peptide possessing metal chelating ability between the side-chains at the i and i + 3th residues was synthesized, and its metal complexes were shown to stabilize the peptide structure and the helical sense.

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Supplementary files

Experimental details and additional spectroscopic data PDF (2662K)

Article information

DOI: https://doi.org/10.1039/B803080D
Article type: Communication
Submitted: 21 Feb 2008
Accepted: 19 Mar 2008
First published: 21 Apr 2008

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Chem. Commun., 2008, 2894-2896

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Decelerated chirality interconversion of an optically inactive 3₁₀-helical peptide by metal chelation

N. Ousaka, N. Tani, R. Sekiya and R. Kuroda, Chem. Commun., 2008, 2894 DOI: 10.1039/B803080D

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Chemical Communications