Issue 25, 2008
From the journal:

Chemical Communications

A potential role for protein tyrosine phosphatase inhibition by a RuIII–edta complex (edta = ethylenediaminetetraacetate) in its biological activity

Debabrata Chatterjee,*a   Anannya Mitra,b   Aviva Levinab  and  Peter A. Lay*b  

* Corresponding authors

a Chemistry Group, Central Mechanical Engineering Research Institute, MG Avenue, Durgapur, India
E-mail: dchat57@hotmail.com
Fax: +91-343-2546745
Tel: +91-343-2546828

b School of Chemistry, The University of Sydney, Australia
E-mail: p.lay@chem.usyd.edu.au
Fax: +61-2-9351 3329
Tel: +61-2-9351 4269

Abstract

[RuIII(edta)(OH2/OH)]1−/2− (edta = ethylenediaminetetraacetate) inhibits protein tyrosine phosphatase (PTP) at physiological pH values in a mechanism that involves binding of the Cys residue of the catalytic domain of the enzyme and similar interactions may be important in the anti-cancer properties of the active forms of many Ru pro-drugs.

Graphical abstract: A potential role for protein tyrosine phosphatase inhibition by a RuIII–edta complex (edta = ethylenediaminetetraacetate) in its biological activity

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Article information

DOI
https://doi.org/10.1039/B803261K
Article type
Communication
Submitted
26 Feb 2008
Accepted
03 Apr 2008
First published
28 May 2008

Chem. Commun., 2008, 2864-2866

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A potential role for protein tyrosine phosphatase inhibition by a RuIII–edta complex (edta = ethylenediaminetetraacetate) in its biological activity

D. Chatterjee, A. Mitra, A. Levina and P. A. Lay, Chem. Commun., 2008, 2864 DOI: 10.1039/B803261K

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