Issue 41, 2008
From the journal:

Chemical Communications

Copper-catalyzed asymmetric allylic substitution with aryl and ethylGrignard reagents†

Khalid B. Selim,a   Ken-ichi Yamadaa  and  Kiyoshi Tomioka*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, Japan
E-mail: tomioka@pharm.kyoto-u.ac.jp
Fax: +81 75 753 4604
Tel: +81 75 753 4553

Abstract

Phenyl- and ethyl-magnesium bromides undergo regioselective asymmetric allylic substitution with high enantioselectivity under the catalysis of chiral amidophosphane–copper(I) complexes.

Graphical abstract: Copper-catalyzed asymmetric allylic substitution with aryl and ethylGrignard reagents

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Article information

DOI
https://doi.org/10.1039/B809140D
Article type
Communication
Submitted
29 May 2008
Accepted
16 Jul 2008
First published
09 Sep 2008

Chem. Commun., 2008, 5140-5142

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Copper-catalyzed asymmetric allylic substitution with aryl and ethylGrignard reagents

K. B. Selim, K. Yamada and K. Tomioka, Chem. Commun., 2008, 5140 DOI: 10.1039/B809140D

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