Issue 43, 2008
From the journal:

Chemical Communications

The first synthesis of N-acetylneuraminic acid 1,7-lactone†

Raffaele Colombo,a   Mario Anastasia,a   Paola Rotaa  and  Pietro Allevi*a  

* Corresponding authors

a Department of Chemistry, Biochemistry and Biotechnology for the Medicine, Via Saldini 50, Milano, Italy
E-mail: pietro.allevi@unimi.it
Fax: 39 0250316040
Tel: 390250316042

Abstract

N-Acetylneuraminic acid is transformed into its until now unavailable and rather unwieldy 1,7-lactone, via the manageable 2-benzyloxycarbonyl N-acetylneuraminic acid 1,7-lactone which generates the free lactone in quantitative yield by hydrogenolysis.

Graphical abstract: The first synthesis of N-acetylneuraminic acid 1,7-lactone

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Article information

DOI
https://doi.org/10.1039/B810447F
Article type
Communication
Submitted
19 Jun 2008
Accepted
16 Jul 2008
First published
23 Sep 2008

Chem. Commun., 2008, 5517-5519

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The first synthesis of N-acetylneuraminic acid 1,7-lactone

R. Colombo, M. Anastasia, P. Rota and P. Allevi, Chem. Commun., 2008, 5517 DOI: 10.1039/B810447F

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