Issue 43, 2008
From the journal:

Chemical Communications

In vivo studies of a platinum(ii) metallointercalator†

Dianne M. Fisher,a   Ronald R. Fenton*a  and  Janice R. Aldrich-Wright*b  

* Corresponding authors

a Centre for Heavy Metals Research, School of Chemistry, The University of Sydney, NSW, Australia
E-mail: ron@fenton.id.au
Fax: +61 2 9351 3329
Tel: +61 2 9351 2060

b School of Biomedical and Health Sciences, University of Western Sydney, Penrith South, Australia
E-mail: J.Aldrich-Wright@uws.edu.au
Fax: +61 2 4620 3025
Tel: +61 2 4620 3218

Abstract

An in vivo study for determining the toxicity and efficacy of [Pt(S,S-dach)(phen)Cl2·1.5H2O·0.5HCl (PHENSS) in female Specific Pathogen Free (SPF) Swiss nude mice bearing PC3 tumour xenografts revealed PHENSS to be non-toxic and effective in decreasing tumour growth.

Graphical abstract: In vivo studies of a platinum(ii) metallointercalator

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Article information

DOI
https://doi.org/10.1039/B811723C
Article type
Communication
Submitted
09 Jul 2008
Accepted
19 Aug 2008
First published
26 Sep 2008

Chem. Commun., 2008, 5613-5615

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In vivo studies of a platinum(II) metallointercalator

D. M. Fisher, R. R. Fenton and J. R. Aldrich-Wright, Chem. Commun., 2008, 5613 DOI: 10.1039/B811723C

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